Radiographic presentation of musculoskeletal involvement in Werner syndrome (adult progeria)
نویسندگان
چکیده
منابع مشابه
Adult Progeria: Werner Syndrome.
Werner's syndrome is an adult premature aging syndrome of autosomal recessive inheritance affecting connective tissues throughout the body.1 The exact etiology remains obscure even though biochemical and connective tissue abnormalities have been postulated.2 The disease involves multiple systems of the body and may be associated with internal malignancy.3 We report a case of a 35 year old man w...
متن کاملExcess of rare cancers in Werner syndrome (adult progeria).
The association between genetic disorders and diverse cancers has provided clues for laboratory research into carcinogenesis. Such an opportunity now arises from studies of cancer in Werner syndrome (WRN). Soft-tissue sarcoma (STS) and benign meningioma have been associated with WRN, an autosomal recessive disorder characterized by premature aging, more commonly reported in Japan than elsewhere...
متن کاملPartial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome
BACKGROUND Laminopathies, due to mutations in LMNA, encoding A type-lamins, can lead to premature ageing and/or lipodystrophic syndromes, showing that these diseases could have close physiopathological relationships. We show here that lipodystrophy and extreme insulin resistance can also reveal the adult progeria Werner syndrome linked to mutations in WRN, encoding a RecQ DNA helicase. METHOD...
متن کاملWerner's Syndrome (Progeria in the Adult)
Fig. 1. Face.-Bird-like appearance, with baldness and premature senility. well-nourished compared to marked atrophy of the limbs. Atrophy of the genitals.
متن کاملWerner syndrome associated with renal involvement.
W syndrome (WS) is an autosomal recessive disease, which is characterized by premature aging, short stature, cataract, dermal atrophy and ulcers, turning white early on hairs, alopecia, vascular calcification, diabetes mellitus, and osteoporosis.1,2 Kidney involvement is rarely seen in WS.3,4 We report a case of WS associated with end stage renal failure without any risk factor. A 29-year-old m...
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ژورنال
عنوان ژورنال: Diagnostic and Interventional Imaging
سال: 2017
ISSN: 2211-5684
DOI: 10.1016/j.diii.2016.10.007